Synthesis and immunological study of α-2,9-oligosialic acid conjugates as anti-group C meningitis vaccines.
نویسندگان
چکیده
α-2,9-Di-, tri-, tetra-, and pentasialic acids were prepared and conjugated with a carrier protein. The resultant glycoconjugates elicited robust T cell-mediated immunity in mice. α-2,9-Trisialic acid was identified as a promising antigen for developing glycoconjugate vaccines against group C Neisseria meningitidis.
منابع مشابه
Fully Synthetic Self-Adjuvanting α-2,9-Oligosialic Acid Based Conjugate Vaccines against Group C Meningitis
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ورودعنوان ژورنال:
- Chemical communications
دوره 51 47 شماره
صفحات -
تاریخ انتشار 2015